Now showing items 1-10 of 10
CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.
Interleukin-7 receptor α (IL-7Rα) is essential for T cell survival and differentiation. Glucocorticoids are potent enhancers of IL-7Rα expression with diverse roles in T cell biology. Here we identify the transcriptional ...
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Induced locomotor hyperactivity on ethanol withdrawal syndrome in rats is inhibited by quetiapine.
Our aim is to investigate the effects of two atypical antipsychotics; quetiapine and olanzapine on locomotor activity that is a sign of ethanol withdrawal syndrome in rats. Adult male Wistar rats were subjects. Ethanol ...
The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: The role of 5-HT3 Receptors.
Tianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect ...
Effects of α-lipoic acid on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in sub-chronic thinner-addicted rats
Abstract: The present study was carried out to determine the effects of sub-chronic thinner addiction on the oxidant− antioxidant balance, the relation between toxicity and oxidative stress, and a possible protective ...
Alzheimer disease and neuroplasticity: New approaches and new targets in pharmacotherapy.
Alzheimer disease (AD) is the major cause of dementia in the aged individuals. It is a neurodegenerative disorder characterized by apoptosis and loss of neurons resulting in synaptic dysfunction in central pathways ...
A new target for diagnosis and treatment of CNS disorders: Agmatinergic system.
A polyamine agmatine is produced through decarboxylation of L -arginine by the enzyme arginine decarboxylase and is a new neurotransmitter in central nervous system (CNS). It has been suggested that agmatine has analgesic, ...
The pharmacological importance of agmatine in the brain
Agmatine is a polyamine that is produced via decarboxylation of l-arginine by the enzyme arginine decarboxylase. It binds to various receptors and has been accepted as a novel neurotransmitter in brain. In experimental ...