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Varenicline disrupts prepulse inhibition only in high-inhibitory rats.
Varenicline, a widely used smoking cessation drug, has partial agonistic activity at α4β2 nicotinic receptors, and full agonistic activity at α7 nicotinic receptors. Thus it may interact with cognitive processes and may ...
Social interaction of rats is related with baseline prepulse inhibition level.
The symptoms of schizophrenia are evaluated in three general categories: positive, negative and cognitivesymptoms. Disruption of prepulse inhibition (PPI) of the acoustic startle reflex is commonly used to modelpositive ...