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dc.contributor.authorAtasever-Arslan, Belkis
dc.contributor.authorFarooqi, Ammad Ahmad
dc.contributor.authorAttar, Rukset
dc.contributor.authorRomero, Mirna Azalea
dc.contributor.authorFahim ul Haq, Muhammad
dc.contributor.authorQadir, Muhammad Imran
dc.date.accessioned2014-09-23T11:54:23Z
dc.date.available2014-09-23T11:54:23Z
dc.date.issued2014
dc.identifier.citation1. Farooqi AA, Attar R, Atasever Arslan B, Romero MA. Recently Emerging Signaling Landscape of Ataxia-telangiectasia Mutated Kinase (ATM). Asian Pac J Cancer Prev. 2014; 15(16): 6485-8.tr_TR
dc.identifier.urihttp://earsiv.uskudar.edu.tr/xmlui/handle/123456789/220
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/25169474
dc.description.abstractResearch over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.tr_TR
dc.language.isoengtr_TR
dc.relation.ispartofseriesSCI-expanded
dc.relation.isversionofhttp://dx.doi.org/10.7314/APJCP.2014.15.16.6485tr_TR
dc.subjectAtaxiatr_TR
dc.subjectTelangiectasia mutated kinasetr_TR
dc.subjectSignalling landscapetr_TR
dc.subjectCancer therapytr_TR
dc.titleRecently Emerging Signaling Landscape of Ataxia-Telangiectasia Mutated (ATM) Kinase.tr_TR
dc.typeArticletr_TR
dc.relation.journalAsian Pacific Journal of Cancer Preventetiontr_TR
dc.contributor.departmentÜsküdar Üniversitesi, Mühendislik Fakültesi, Moleküler Biyoloji ve Genetiktr_TR
dc.contributor.authorIDTR144851tr_TR


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