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dc.contributor.authorBozkurt, Ayhan
dc.contributor.authorBilge, S. Sırri
dc.contributor.authorIlkaya, Fatih
dc.contributor.authorCiftcioglu, Engin
dc.contributor.authorUzbay, Tayfun
dc.contributor.authorKesim, Yuksel
dc.date.accessioned2014-10-24T11:39:46Z
dc.date.available2014-10-24T11:39:46Z
dc.date.issued2012
dc.identifier.citationBilge, S.S., Bozkurt, A., İlkaya, F., Çiftçioğle, E., Kesim, Y., Uzbay, T.I. The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: The role of 5-HT3 Receptors. European Journal of Pharmacology, 681:44-49, 2012.tr_TR
dc.identifier.urihttp://earsiv.uskudar.edu.tr/xmlui/handle/123456789/348
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/pubmed/22348811
dc.description.abstractTianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect of tianeptine is mediated by serotonergic (5-HT2,3) and noradrenergic (α1,2) receptor subtypes. Male Sprague Dawley rats (250–300 g) were supplied with a venous catheter, for drug administrations, and enameled nichrome electrodes, for electromyography, at external oblique musculature. Colorectal distension (CRD) was employed as the noxious visceral stimulus and the visceromotor response (VMR) to CRD was quantified electromyographically before and 5, 15, 30, 60, 90 and 120 min after tianeptine administration. Antagonists were administered 10 min before tianeptine for their ability to change tianeptine antinociception. Intravenous administration of tianeptine (2.5–20 mg/kg) produced a dose-dependent reduction in VMR. Administration of 5-HT3 receptor antagonist ondansetron (0.5, 1 and 2 mg/kg), but not 5-HT2 receptor antagonist ketanserine (0.5, 1 and 2 mg/kg), reduced the antinociceptive effect of tianeptine (10 mg/kg). In addition, administration of α1-adrenoceptor antagonist prazosin (1 mg/kg) or α2-adrenoceptor antagonist yohimbine (1 mg/kg) did not cause any significant effect on the tianeptine-induced antinociception. Our data indicate that intravenous tianeptine exerts a pronounced antinociception against CRD-induced visceral pain in rats, and suggests that the antinociceptive effect of tianeptine appears to be mediated in part by 5-HT3 receptors, but does not involve 5-HT2 receptors or α-adrenoceptors.tr_TR
dc.language.isoengtr_TR
dc.relation.ispartofseriesuluslararası diğer;
dc.relation.isversionof10.1016/j.ejphar.2012.01.043tr_TR
dc.subjectTianeptinetr_TR
dc.subjectVisceral paintr_TR
dc.subjectAntinociceptiontr_TR
dc.subjectColorectal distensiontr_TR
dc.subjectAntidepressanttr_TR
dc.subjectRattr_TR
dc.titleThe antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: The role of 5-HT3 Receptors.tr_TR
dc.typeArticletr_TR
dc.relation.journalEuropean Journal of Pharmacologytr_TR
dc.contributor.departmentÜsküdar Üniversitesi, Mühendislik Fakültesi, Moleküler Biyoloji ve Genetiktr_TR
dc.contributor.authorIDTR12488tr_TR


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