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dc.contributor.authorGoktalay, Gokhan
dc.contributor.authorKayir, Hakan
dc.contributor.authorUlusoy, Gokhan
dc.contributor.authorUzbay, Tayfun
dc.date.accessioned2014-10-24T12:19:14Z
dc.date.available2014-10-24T12:19:14Z
dc.date.issued2014
dc.identifier.citationGoktalay, G., Kayir, H., Ulusoy, G.K., Uzbay, T. Social interaction of rats is related with baseline prepulse inhibition level. Neuroscience Letter, 582: 125-129, 2014.tr_TR
dc.identifier.urihttp://earsiv.uskudar.edu.tr/xmlui/handle/123456789/351
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S0304394014007344
dc.description.abstractThe symptoms of schizophrenia are evaluated in three general categories: positive, negative and cognitivesymptoms. Disruption of prepulse inhibition (PPI) of the acoustic startle reflex is commonly used to modelpositive and cognitive symptoms in experimental animals. On the other hand, deficient social interaction(SI) is a common model of negative symptoms. Here we tested whether PPI provides information aboutnegative symptoms by using a SI test. Baseline PPI and its relation with anxiety-like behavior were alsoexamined with elevated plus maze (EPM) test. In the first experiment, baseline PPI levels of 30 Wistarrats were measured and animals with the highest 1/3 and the lowest 1/3 of PPI scores were respectivelyassigned in high-inhibitory (HI) and low-inhibitory (LI) groups. Subsequently, rats in the HI and LI groupswere paired with animals from the same group and tested for SI. In the second experiment, another batchof animals was assigned to HI and LI groups and they were investigated in the EPM test. The results demon-strate a significant difference between the PPI values of HI and LI groups. Both the SI time and the movingdistance of LI rats were significantly lower, and the average distance between rat pairs was significantlylonger than HI rats. In the EPM test LI and HI rats showed similar levels of anxiety-like behaviors, howeverour results imply that performance of the rats in the SI test is related to baseline PPI levels. Thus PPI testcan provide predictive information about the outcome of animal models for negative symptoms in rats.tr_TR
dc.language.isoengtr_TR
dc.relation.ispartofseriesSCI;
dc.relation.isversionof10.1016/j.neulet.2014.09.010tr_TR
dc.subjectSocial interactionSocial with drawal Anxiety Prepulse inhibition (PPI)tr_TR
dc.subjectSchizophrenia Rat(s)
dc.titleSocial interaction of rats is related with baseline prepulse inhibition level.tr_TR
dc.typeArticletr_TR
dc.relation.journalNeuroscience Lettertr_TR
dc.contributor.departmentÜsküdar Üniversitesi, Mühendislik Fakültesi, Moleküler Biyoloji ve Genetiktr_TR
dc.contributor.authorIDTR12488tr_TR


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