Transmitter-mediated action of neuromedin S on Passive avoidance learning in rats
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The possible involvement of different neurotransmitters in the action of neuromedin S (NMS) in the memory consolidation of passive avoidance behavior was studied by pretreating rats with different receptor blockers which alone did not change the test. The involvement of cholinergic, dopaminergic, adrenergic, serotonergic, opiate and GABA-ergic receptors and nitric oxide was tested. The animals were pretreated with the non selective muscarinic acetylcholine receptor antagonist, atropine, the non selective β-adrenergic receptor antagonist phenoxybenzamine, the β-adrenergic receptor antagonist propranolol, the D2, D3, D4 dopamine receptor antagonist haloperidol , the non selective 5-HT2 serotonergic receptor antagonist cyproheptadine, the nonselective opioid receptor antagonist naloxone,. the γ-aminobutyric acid subunit A (GABA-A) receptor antagonist bicuculline, or the nitric oxide synthase inhibitor nitro-L-arginine. Atropine, haloperidol, phenoxybenzamine, propranolol, cyproheptadine, naloxone and nitro-Larginine prevented the effects of NMS on passive avoidance learning. Bicuculline did not change the effects of NMS. The results demonstrate that muscarinic acetylcholine, α- and β- adrenergic, dopaminergic , 5-HT2 serotonergic and opioid receptors and nitric oxide are involved as mediators. In the action of NMS on the consolidation of passive avoidance learning.