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  •   e-Arsiv@Uskudar : Dijital Arşiv Sistemi
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Türk Milli Bisikletçilerde Alfa- Aktinin-3 R577X Polimorfizm Dağılımının Belirlenmesi

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Tarih
2017-06-01
Yazar
Kaman, Tuğba
Kapıcı, Sezgin
Sercan, Canan
Konuk, Muhsin
Ulucan, Korkut
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Özet
The aim of this study was to determine the allelic distribution of alpha- actinin-3 (ACTN3) R577X polymorphisms in a total of 36 national cyclist team, 13female and 23 male. DNA samples from the players were isolated from Blood samples by using commercial DNA isolation kit. Genotyping of the samples was accomplished by Real-Time PCR technique. 12 of the examined bicycler had RR, 10 had RX and 14of the bicycler had XX genotype for the ACTN3 R577X polymorphism. When we examine them according to genders, 4 of the 13 female cyclist had RR,2 had RX and 7 had XX genotypes. For males, 8 of the 23 male cyclist had RR, 8 had RX and 7 had XX genotypes . ACTN3 was counted as 10 in females and 24 in males, whereas X allele was 16 in females and 22 in males. Our results showed that ACTN3 XX genotype and X allele dominated in our cohort. We hope that this first pilot study carried out in national cyclist team will guide further studies with extended numbers of players.
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http://earsiv.uskudar.edu.tr/xmlui/handle/123456789/683
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