Evaluation of antibacterial, antioxidant and DNA protective capacity of Chenopodium album’s ethanolic leaf extract
Korcan, Safiye Elif
Erdogmus, Sevim Feyza
Cigerci, Ibrahim Hakki
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We have investigated the antibacterial effects of Chenopodium album’s ethanolic leaf extract (CAE) on all the Gram (+) and Gram ( ) microorganisms and evaluated the protective effects of CAE on both yeast and human mononuclear leukocytes’ genomic DNA upon oxidative shock. Antibacterial activity was recorded on Bacillus subtilis with 13 mm of inhibition zone. Total oxidative status (TOS) and the total antioxidative status (TAS) levels were determined to evaluate the antioxidant activity of CAE. Results indicated that there was a good correlation between dose of CAE and TAS levels. We also observed that CAE protect the DNA of both yeast and mononuclear leukocytes against the damaging effect of hydrogen peroxide. The comet assay, applied on both Saccharomyces cerevisiae BY4741 (MATa his3D1 leu2D0 met15D0 ura3D0) and human leukocytes, results suggested that there was statistically significant correlation between CAE dilutions and antigenotoxic activity.