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dc.contributor.authorKarahan, Mesut
dc.contributor.authorMustafaeva, Zeynep
dc.contributor.authorOzturkcan, Arda S.
dc.date.accessioned2014-09-30T11:37:13Z
dc.date.available2014-09-30T11:37:13Z
dc.date.issued2013
dc.identifier.citationKarahan, M., Ozturkcan, S. A., & Mustafaeva, Z. (2013). Antitumor activity of polyelectrolytes-metal complexes. Romanian Biotechnological Letters, 18(4), 8447-8455.tr_TR
dc.identifier.urihttp://earsiv.uskudar.edu.tr/xmlui/handle/123456789/260
dc.identifier.urihttp://www.rombio.eu/vol18nr4/8%20Mesut%20Karahan.pdf
dc.description.abstractThe interactions between anionic polyelectrolytes [polyacrylic acid, poly(methyl vinyl etherco- maleic anhydrate)] and copper ions in aqueous solution (pH 7.0) were investigated by dynamic light scattering, UV-visible and fourier transform infrared spectroscopic techniques. Viscosity was also measured by ubbelohde automatic viscometer. Observations indicate that the ratio of ingredients, the nature of the metal ions and their environmental conditions affect the formation of soluble and insoluble Polyelectrolyte-Metal complexes. These binary complexes were tested in vitro as potential antitumor agents with Human Embryonic Kidney 293 cells. Depending on the ratio and sequence of mixing of components in the formation of Polyelectrolyte-Copper complexes, it was observed that the most stable water soluble polycomplexes prepared exhibited a high antitumor activity in the ratio of nCu 2+/nAA: 0.4and nCu2+/nMVE-MA: 0.5, respectively.tr_TR
dc.language.isoengtr_TR
dc.relation.ispartofseriesSCI-expanded;
dc.subjectBiopolymertr_TR
dc.subjectcopper ionstr_TR
dc.subjectpolyelectrolyte-metal complextr_TR
dc.subjectantitumor activitytr_TR
dc.titleAntitumor Activity of Polyelectrolytes-metal Complexestr_TR
dc.typeArticletr_TR
dc.relation.journalRomanian Biotechnological Letterstr_TR
dc.contributor.departmentÜsküdar Üniversitesi, Mühendislik Fakültesi, Biyomühendisliktr_TR
dc.contributor.authorIDTR103146tr_TR


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