Sertraline induced angioedema

Abstract

To editor, Selective serotonin reuptake inhibitors (SSRIs) are reliable drugs (Kostev et al, 2014). Only one angioedema case due to sertraline was reported (Dadic-Hero et al, 2011). In this case, angioedema has also developed with both sertraline and escitalopram (another SSRI). Cross-allergic reactions might be seen in similar drugs. Case Sertraline (25 mg/day) treatment was started 51-year-old male patient with a diagnosis of depression. He called after 3 hours later first dose with complaints of swelling of the lips and tongue and sent his own photo. Thereupon dermatology consultation was requested. In dermatological examination angioedema (Quincke's edema) was diagnosed. Because it couldn’t find another reason, sertraline treatment was terminated. Edema was decreased treatment with antihistaminic. After 2 weeks, sertraline (12.5 mg/day) was started again and 3-4 hours after taking the first dose of sertraline, he sent his own photo with complaints of the same symptoms. Sertraline treatment was terminated due to repeated angioedema. Amitriptyline (10 mg/day) treatment was started and angioedema didn’t occur although the dose of it was increased to 100 mg/day. In our case, angioedema was not developed with amitriptyline, a tricyclic antidepressant (TCA). It has been reported that amitriptyline might be used in the treatment of angioedema (Guarneri et al, 2014). It may be appropriate to plan a medication from a different group when allergic reactions occur. Sincerely,