Polyamines, including spermidine, spermine, and agmatine, serve several brain-specific functions. Polyamine transport mechanisms may account for the redistribution of these organic cations, which may also be synaptically ...

Agmatine may act as a neurotransmitter or neuromodulator. Behaviorally, agmatine exerts antidepressant-like effects. The enzyme agmatinase degrades and thereby inactivates agmatine. The gene coding for human agmatinase ...