Papilledema Due to Mirtazapine
Date
2016-05-01Author
Ceylan, Mehmet Emin
Evrensel, Alper
Cömert, Gökçe
Metadata
Show full item recordAbstract
Background: Mirtazapine is a tetracyclic antidepressant
that enhances both noradrenergic and serotonergic
transmission. The most common cause of papilledema
is increased intracranial pressure due to brain
tumor. Also it may occur as a result of idiopathic intracranial
hypertension (IIH, pseudo tumor cerebri).
Moreover, papilledema may also develop due to retinitis,
vasculitis, Graves’ disease, hypertension, leukemia,
lymphoma, diabetes mellitus and radiation.
Case Report: In this article, a patient who developed
papilledema while under treatment with mirtazapine
(30 mg/day) for two years and recovered with termination
of mirtazapine treatment was discussed to
draw the attention of clinicians to this side effect of
mirtazapine.
Conclusion: Idiopathic intracranial hypertension and
papilledema due to psychotropic drugs has been reported
in the literature. Mirtazapine may rarely cause
peripheral edema. However, papilledema due to mirtazapine
has not been previously reported. Although
papilledema is a very rare side effect of an antidepressant
treatment, fundoscopic examinations of patients
must be performed regularly.