|dc.identifier.citation||Diffusion-Weighted Imaging Study in Euthymic Patients with Bipolar I Disorder, Doğan, Orhan, (2012)||tr_TR
|dc.description.abstract||Diffusion-weighted imaging study in euthymic
patients with bipolar I disorder
Objective: To examine the possible presence of white
matter abnormalities and apparent diffusion coefficient (ADC)
changes by using diffusion-weighted magnetic resonance
(MR) imaging, in patients with euthymic bipolar I disorder.
Method: Thirty patients (12 women, 18 men) were
included in this study. The patients, whose total Young
Mania Rating Scale points were 5 or less at least for
four weeks, and whose total Hamilton Depression Rating
Scale points were 7 or less were considered as euthymic.
The control group was consisted of age and gender
matched 30 healthy individuals. ADC values were obtained
symmetrically from the frontal, temporal, and occipital
lobes and the genu of the corpus callosum, where white
matter tissue was the largest.
Results: The mean ADC value of the bipolar group was
determined as 856.53±88.31x10-3mm/s, and that of the
control group was 778.89±89.67x10-3mm/s. The mean ADC
values on the right frontal area was found to be lower in
bipolar patients as compared to that of the control group,
but the difference was statistically insignificant. However,
it was found significantly lower on the left hemisphere
(p<0.05). The increases of the mean ADC values obtained
from both right and left temporal and occipital lobes of
bipolar group were found to be statistically significant as
compared to those of the control group (p<0.05).
Conclusions: According to the results of this study, the
increased ADC values in euthymic bipolar patients may
probably be related to the disintegration of white matter.
Besides, decreased ADC values obtained from the frontal
areas suggest that the disintegration might be reversible.||tr_TR
|dc.title||Diffusion-Weighted Imaging Study in Euthymic Patients with Bipolar I Disorder||tr_TR
|dc.relation.journal||Journal of Mood Disorders||tr_TR
|dc.contributor.department||Üsküdar Üniversitesi, İnsan ve Toplum Bilimleri Fakültesi, Psikoloji Bölümü, Psikoloji Pr.||tr_TR