TWO CASES OF SCHIZOPHRENIA; THE RELATIONSHIP BETWEEN CAVUM SEPTUM PELLUCIDUM AND CLINICAL COURSE
Cetinay Aydin, Pınar
Berkol, Tonguc Demir
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Septum pellucidum, which forms the medial wall of the lateral ventricles, consists of two laminates. Cavum septum pellucidum (CSP) is deﬁned when there is a space between these laminae. In some MRI studies have shown a higher rate of large CSP in patients with schizophrenia than in normal subjects. Looking at the literature on psychiatric disorders, CSP has been shown to be most associated with schizophrenia. Large CSP supports the neurodevelopmental model, which is one of the etiological explanations of schizophrenia. In our study, two patients with a diagnosis of CSP are mentioned. One of our patients is a ﬁrst episode of schizophrenia, and the other one chronic schizophrenia patient with a history of multi-drug resistance. The ﬁrst episode of schizophrenia is consistent with the information available in the literature in terms of the severity of symptoms, weak-response to treatment, and insufﬁciency of neuropsychological tests. The apparent deﬁcit of the chronic schizophrenia patient suggests that CSP has a neurodevelopmental model in the etiology of schizophrenia, as well as the duration of the disease and non-compliance with treatment. There is no study in the literature comparing the response to treatment with large CSP in schizophrenia. It is thought that investigation of response to treatment in future studies is important for demonstrating the effects of neurodevelopmental model on the treatment of psychiatric disorders.