Now showing items 1-10 of 20
Chronic melatonin treatment reverses disruption of prepulse inhibition in pinealectomized and pinealectomized-plus-ovariectomized rats.
Although melatonin has been implicated in several neurophysiological systems, data on the relationship of melatonin with psychosis such as schizophrenia are limited and contradictory. Chronic effects of melatonin on ...
Psikotrop ilaç etkileşmeleri
Induced locomotor hyperactivity on ethanol withdrawal syndrome in rats is inhibited by quetiapine.
Our aim is to investigate the effects of two atypical antipsychotics; quetiapine and olanzapine on locomotor activity that is a sign of ethanol withdrawal syndrome in rats. Adult male Wistar rats were subjects. Ethanol ...
The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: The role of 5-HT3 Receptors.
Tianeptine is an unusual tricyclic antidepressant drug. In this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect ...
Varenicline disrupts prepulse inhibition only in high-inhibitory rats.
Varenicline, a widely used smoking cessation drug, has partial agonistic activity at α4β2 nicotinic receptors, and full agonistic activity at α7 nicotinic receptors. Thus it may interact with cognitive processes and may ...
Increased plasma agmatine levels in patients with schizophrenia
Agmatine is an endogenous substance, synthesized from L-arginine, and it is proposed to be a new neurotransmitter. Preclinical studies indicated that agmatine may have an important role in the pathophysiology of ...
Agomelatine strongly interacts with zwitterionic DPPC and charged DPPG membranes.
Depression is one of the most common psychiatric diseases in the population. Agomelatine is a novel antidepressant drug with melatonin receptor agonistic and serotonin 5-HT2C antagonistic properties. Furthermore, being ...
GATA ASKERİ TIP FAKÜLTESİ’NDE GERÇEKLEŞTİRİLEN MADDE BAĞIMLILIĞI KONULU PANELİ DİNLEMEYE GELENLERDE BAĞIMLILIK YAPICI MADDE KULLANIMININ ANKET YÖNTEMİ İLE SORGULANMASI
Amaç: Madde bağımlılığı özellikle gelişmekte olan ülkelerde giderek artmakta olan bir sorundur. 1998 yılında Gülhane Askeri Tıp Akademisi (GATA) Askeri Tıp Fakültesi’nde düzenlenen “madde bağımlılığı” konulu panelde, bir ...
Social interaction of rats is related with baseline prepulse inhibition level.
The symptoms of schizophrenia are evaluated in three general categories: positive, negative and cognitivesymptoms. Disruption of prepulse inhibition (PPI) of the acoustic startle reflex is commonly used to modelpositive ...