Show simple item record

dc.contributor.authorBulut, Mahmut
dc.contributor.authorGergerlioglu, H. Serdar
dc.contributor.authorSavas, Haluk A.
dc.contributor.authorUzbay, Tayfun
dc.contributor.authorBilgic, M. Tuba
dc.contributor.authorGergerlioglu, Nursadan
dc.contributor.authorBaltaci, Yasemin
dc.contributor.authorBosnak, Mehmet
dc.contributor.authorBagci, Cahit
dc.date.accessioned2014-10-24T11:32:47Z
dc.date.available2014-10-24T11:32:47Z
dc.date.issued2012
dc.identifier.citationGergerlioğlu, H.S., Savaş, H.A., Boşnak, M., Bağcı, C., Baltacı, Y., Bilgiç, M.T., Bulut, M., Gergerlioğlu, N, Uzbay, İ.T. Induced locomotor hyperactivity on ethanol withdrawal syndrome in rats is inhibited by quetiapine. European Journal of Basic Medical Science, 2: 112-117, 2012.tr_TR
dc.identifier.urihttp://earsiv.uskudar.edu.tr/xmlui/handle/123456789/347
dc.identifier.urihttp://ejbms.org/upload/sayi/20/JBMS-49.pdf
dc.description.abstractOur aim is to investigate the effects of two atypical antipsychotics; quetiapine and olanzapine on locomotor activity that is a sign of ethanol withdrawal syndrome in rats. Adult male Wistar rats were subjects. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 30 days. Control rats were pair fed an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. Quetiapine (10 mg/kg), olanzapine (5 mg/kg) and saline were injected to the rats intraperitoneally 7 days after ethanol withdrawal syndrome and the last one 30 min before ethanol withdrawal testing. After 2nd hour of ethanol withdrawal, rats were observed for 5 min and withdrawal signs that included locomotor hyperactivity were recorded. We have found increased vertical and horizontal locomotor activity in ethanol withdrawal group to control and reduced vertical and horizontal locomotor activity in quetiapine-injected rats. In olanzapine injected rats were seen no reduced locomotor activity. Significant inhibitory effects were produced by quetiapine on the signs of ethanol withdrawal. Our results suggest that acute quetiapine treatment has some beneficial efects on ethanol withdrawal in rats. Thus, this drug may be useful for treatment of ethanol withdrawal syndrome.tr_TR
dc.language.isoengtr_TR
dc.relation.ispartofseriesuluslararası diğer;
dc.subjectLocomotor activitytr_TR
dc.subjectEthanol withdrawal syndrometr_TR
dc.subjectQuetiapinetr_TR
dc.subjectOlanzapinetr_TR
dc.subjectRat model.tr_TR
dc.titleInduced locomotor hyperactivity on ethanol withdrawal syndrome in rats is inhibited by quetiapine.tr_TR
dc.typeArticletr_TR
dc.relation.journalEuropean Journal of Basic Medical Sciencetr_TR
dc.contributor.departmentÜsküdar Üniversitesi, Mühendislik Fakültesi, Moleküler Biyoloji ve Genetiktr_TR
dc.contributor.authorIDTR12488tr_TR


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record