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dc.contributor.authorHizli Sayar, Gokben
dc.contributor.authorEryilmaz, Gul
dc.contributor.authorOzten, Eylem
dc.contributor.authorGogcegoz Gul, Isil
dc.date.accessioned2014-09-25T14:13:56Z
dc.date.available2014-09-25T14:13:56Z
dc.date.issued2014
dc.identifier.citationDecreased mean platelet volume in panic disorder. Göğcegöz G, Eryilmaz G, Ozten E, Hızlı Sayar G. Neuropsychiatric Disease and Treatment 2014:10 1665–1669. doi: 10.2147/NDT.S69922tr_TR
dc.identifier.urihttp://earsiv.uskudar.edu.tr/xmlui/handle/123456789/230
dc.identifier.urihttps://www.dovepress.com/decreased-mean-platelet-volume-in-panic-disorder-peer-reviewed-article-NDT
dc.description.abstractAIM: The relationship between psychological stress and platelet activation has been widely studied. It is well known that platelets may reflect certain biochemical changes that occur in the brain when different mental conditions occur. Platelet 5-hydroxytryptamine (5-HT) is also extensively studied in psychiatry. The mean platelet volume (MPV), the accurate measure of platelet size, has been considered a marker and determinant of platelet function. The aim of the present study was to search for any probable difference in the MPV of subjects with panic disorder (PD). METHODS: A total of 37 drug-free subjects, aged 18 to 65 years, diagnosed with PD, with or without agoraphobia, according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth edition (DSM-IV) criteria and 45 healthy control subjects were included in the study. Platelet count and MPV were measured and recorded for each subject. RESULTS: There were no statistically significant differences between groups in terms of female/male ratio, age, or body mass index between the PD group and control group (P=0.91, P=0.82, and P=0.93, respectively). The MPV was found to be significantly lower in the PD group compared with the control group (8.8±0.9 fL vs 9.2±0.8 fL; P=0.02). All the participants had MPV values in the standard range of 6.9-10.8 fL. CONCLUSION: We concluded that abnormalities of the 5-HT1A receptor function in the central nervous system of subjects with a diagnosis of PD are also mirrored in as an alteration in platelet activity. Measurements of platelet activity may be used as a tool for neuropsychiatric and psychopharmacological research and for studying how certain mental diseases and medications affect the central nervous system.tr_TR
dc.language.isoengtr_TR
dc.relation.ispartofseriesSCI-expanded;
dc.relation.isversionof10.2147/NDT.S69922tr_TR
dc.subject5-HTtr_TR
dc.subjectThrombocytetr_TR
dc.subjectAnxietytr_TR
dc.titleDecreased mean platelet volume in panic disordertr_TR
dc.typeArticletr_TR
dc.relation.journalNeuropsychiatric Disease and Treatmenttr_TR
dc.contributor.departmentÜsküdar Üniversitesi, NPSUAMtr_TR
dc.contributor.authorIDTR25221tr_TR


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