Analysis of Brain Functional Changes in High-Frequency Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression
Özet
Repetitive transcranial magnetic stimulation (rTMS) is a treatment procedure that uses magnetic fields to stimulate nerve cells in
the brain, and is associated with significant improvements in clinical symptoms of major depressive disorder (MDD). The effect
of rTMS treatment on the brain can be evaluated by cordance, a quantitative electroencephalography (QEEG) method that
extracts information from absolute and relative power of EEG spectra. In this study, to analyze brain functional changes, preand
post-rTMS, QEEG data were collected from 6 frontal electrodes (Fp1, Fp2, F3, F4, F7, and F8) in 2 slow bands (delta and
theta) for 55 MDD subjects. To examine brain changes, cordance scores were determined, using repeated-measures analysis of
variance (ANOVA). High-frequency rTMS was associated with cordance decrease in left frontal and right prefrontal regions in
both delta and theta for nonresponders; it was associated with cordance increase in all right and left frontal electrodes, except
F8, for responders.