Recently Emerging Signaling Landscape of Ataxia-Telangiectasia Mutated (ATM) Kinase.
Özet
Research over the years has progressively and sequentially provided near complete resolution of regulators
of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase
(ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling
and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There
is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review,
we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a
therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy
and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.