TWO CASES OF SCHIZOPHRENIA; THE RELATIONSHIP BETWEEN CAVUM SEPTUM PELLUCIDUM AND CLINICAL COURSE
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Date
2018-10-25Author
Cetinay Aydin, Pınar
Sert, Engin
Yıldırım, Yusuf
Berkol, Tonguc Demir
Kunt, Sevilay
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Show full item recordAbstract
Septum pellucidum, which forms the medial wall of the lateral ventricles, consists of two laminates. Cavum septum pellucidum
(CSP) is defined when there is a space between these laminae. In some MRI studies have shown a higher rate of large CSP
in patients with schizophrenia than in normal subjects. Looking at the literature on psychiatric disorders, CSP has been shown
to be most associated with schizophrenia. Large CSP supports the neurodevelopmental model, which is one of the etiological
explanations of schizophrenia. In our study, two patients with a diagnosis of CSP are mentioned. One of our patients is a first
episode of schizophrenia, and the other one chronic schizophrenia patient with a history of multi-drug resistance. The first episode
of schizophrenia is consistent with the information available in the literature in terms of the severity of symptoms, weak-response
to treatment, and insufficiency of neuropsychological tests. The apparent deficit of the chronic schizophrenia patient suggests that
CSP has a neurodevelopmental model in the etiology of schizophrenia, as well as the duration of the disease and non-compliance
with treatment. There is no study in the literature comparing the response to treatment with large CSP in schizophrenia. It is thought
that investigation of response to treatment in future studies is important for demonstrating the effects of neurodevelopmental model
on the treatment of psychiatric disorders.