Başlık için Moleküler Biyoloji ve Genetik Bölümü listeleme
Toplam kayıt 36, listelenen: 1-20
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A new target for diagnosis and treatment of CNS disorders: Agmatinergic system.
(2012)A polyamine agmatine is produced through decarboxylation of L -arginine by the enzyme arginine decarboxylase and is a new neurotransmitter in central nervous system (CNS). It has been suggested that agmatine has analgesic, ... -
Agomelatine strongly interacts with zwitterionic DPPC and charged DPPG membranes.
(2014)Depression is one of the most common psychiatric diseases in the population. Agomelatine is a novel antidepressant drug with melatonin receptor agonistic and serotonin 5-HT2C antagonistic properties. Furthermore, being ... -
Alzheimer disease and neuroplasticity: New approaches and new targets in pharmacotherapy.
(2012)Alzheimer disease (AD) is the major cause of dementia in the aged individuals. It is a neurodegenerative disorder characterized by apoptosis and loss of neurons resulting in synaptic dysfunction in central pathways ... -
CD8 lineage-specific regulation of interleukin-7 receptor expression by the transcriptional repressor Gfi1.
(2012)Interleukin-7 receptor α (IL-7Rα) is essential for T cell survival and differentiation. Glucocorticoids are potent enhancers of IL-7Rα expression with diverse roles in T cell biology. Here we identify the transcriptional ... -
Chronic melatonin treatment reverses disruption of prepulse inhibition in pinealectomized and pinealectomized-plus-ovariectomized rats.
(2013)Although melatonin has been implicated in several neurophysiological systems, data on the relationship of melatonin with psychosis such as schizophrenia are limited and contradictory. Chronic effects of melatonin on ... -
Cytoplasmic domain of delta subunit is important for the extra-synaptic targeting of GABA(A) receptor subtypes
(Journal of Integrative Neuroscience, 2014-09-16)GABAA receptors (GABAARs) are hetero-pentameric chloride channels and the primary sites for fast synaptic inhibition. We have expressed recombinant g2 and d subunits of GABAARs in cultured hippocampal neurons to analyze ... -
Dexmedetomidine induces conditioned place preference in rats: Involvement of opioid receptors
(2016)Dexmedetomidine (DEX) is an alpha-2 adrenergic agonist drug recently introduced to anesthesia practice. Certain agents used in anesthesia practice have been associated with abuse and addiction problems; however, few ... -
Effects of Early Postnatal Alcohol Exposure on the Developing Retinogeniculate Projections in C57BL/6 Mice
(2013-05)Previous studies on the adverse effects of perinatal exposure to ethanol (EtOH) on the developing visual system mainly focused on retinal and optic nerve morphology. The aim of the present study was to investigate whether ... -
Effects of micro environmental factors on natural killer activity (NK) of beta thalassemia major patients.
(2013)The physiological mechanisms of decreased NK activity of b-Thalassemia major (BTM) patients are unknown. To assess in vitro effects of mononuclear cells and their cytokine secretion on NK activity, we compared activator ... -
Effects of α-lipoic acid on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in sub-chronic thinner-addicted rats
(2012)Abstract: The present study was carried out to determine the effects of sub-chronic thinner addiction on the oxidant− antioxidant balance, the relation between toxicity and oxidative stress, and a possible protective ... -
Efficacy of single-chamber microbial fuel cells for removal of cadmium and zinc with simultaneous electricity production
(2013-11-07)Simultaneous high power generation (3.6 W/m2) and high Cd (90%) and Zn (97%) removal efficiencies were demonstrated in a single chamber air-cathode microbial fuel cell (MFC). The maximum tolerable concentrations (MTCs) ... -
Evaluation of antibacterial, antioxidant and DNA protective capacity of Chenopodium album’s ethanolic leaf extract
(2013)We have investigated the antibacterial effects of Chenopodium album’s ethanolic leaf extract (CAE) on all the Gram (+) and Gram ( ) microorganisms and evaluated the protective effects of CAE on both yeast and human ... -
Evaluation of DNA Damage in Eurasian Marsh Frogs (Pelophylax ridibundus) by Comet Assay for Determination of Possible Pollution in the Different Lakes in Central Anatolia, Turkey
(2013)In the present study, adult Eurasian marsh frogs, Pelophylax ridibundus, and water samples were collected from a reference lake and three water bodies in central Anatolia, Turkey, to evaluate the water for chemical pollutants ... -
Examination of age-dependent effects of fetal ethanol exposure on behavior, hippocampal cell counts, and doublecortin immunoreactivity in rats
(2013-10-29)Ethanol is known as a potent teratogen having adverse effects on brain and behavior. However, some of the behavioral deficits caused by fetal alcohol exposure and well expressed in juveniles ameliorate with maturation may ... -
Hydrogen production profiles using furans in microbial electrolysis cells
(2017)Microbial electrochemical cells including microbial fuel cells (MFCs) and microbial electrolysis cells (MECs) are novel biotechnological tools that can convert organic substances in wastewater or biomass into electricity ... -
Increased plasma agmatine levels in patients with schizophrenia
(2013-04-02)Agmatine is an endogenous substance, synthesized from L-arginine, and it is proposed to be a new neurotransmitter. Preclinical studies indicated that agmatine may have an important role in the pathophysiology of ... -
Induced locomotor hyperactivity on ethanol withdrawal syndrome in rats is inhibited by quetiapine.
(2012)Our aim is to investigate the effects of two atypical antipsychotics; quetiapine and olanzapine on locomotor activity that is a sign of ethanol withdrawal syndrome in rats. Adult male Wistar rats were subjects. Ethanol ... -
Investigation of the role of alpha-2 adrenergic receptors on prepulse inhibition of acoustic startle reflex in rats
(2016)Objectives: Alpha-2 adrenergic receptors target several behavioral functions. These receptors may connect with the brain pathways mediating sensorimotor gating system that associate with psychoses, and the literature ... -
Is It Possible To Understand The Brain By Only Neuroscience? New Expansions And Approaches From Neurological Sciences To Social Sciences In The Brain Century
(2016)Geçtiğimiz yüzyıl boyunca beyni anlamaya yönelik çalışmalar tıp alanında ve özellikle nöroanatomi, nöroloji ve beyin cerrahisi alanlarında yoğunlaşmıştı. Yüzyılın ikinci yarısından itibaren çok önemli bilimsel keşiflerle ...